Journal of Clinical Case Reports Medical Images and Health Sciences

Audit on incidence of Trastuzumab induced Cardiac toxicity in day care Oncology at a tertiary care hospital, Karachi, Pakistan by Arifa Aziz in Journal of Clinical Case Reports Medical Images and Health Sciences  Abstract Background:  Trastuzumab is a monoclonal antibody that inhibits tumor cell growth by binding to the extracellular region of the HER 2 protein and blocking the signalling pathway with overexpressed HER 2 positive breast cancer patients. Mostly presented at an advanced stage and have a significantly shortened disease-free and overall survival. Our objective is to find out the frequency of cardiac toxicity with trastuzumab given subcutaneous,  Method:  Questionnaire form for audit was developed which included questions on shortness of breath, palpitation, edema feet, chest pain and echocardiogram report. Trastuzumab is given through subcutaneous route at dose of 600 mg and eechocardiogram monitored at every 3 months. Data collected from April 2022 ti...

Stevens-Johnson syndrome, with ocular complications and unfavourable outcome in Marieta Dumitrache by Journal of Clinical Case Reports Medical Images and Health Sciences Abstract Stevens-Johnson syndrome (SJS) is an acute, rare but serious vasculitis, triggered by a type III hypersensitivity reaction, clinically manifested by a maculo-vesiculo-bullous erythematous eruption and hemorrhagic skin-mucosal erosions, accompanied by rapidly progressive complications. SJS is an important cause of ocular morbidity. The ocular manifestations in SJS are multiple, variable, some very serious, affecting the eyelids, conjunctiva, cornea (infiltrate, corneal ulcerations, with or without corneal perforation), possibly accompanied by ocular complications and sequelae (cicatricial eyelid lesions, corneal perforation, endophthalmitis, corneal leukoma, corneal neovascularization, vision loss). We present the case of a female patient with SJS with ocular manifestations, with acute onset, after...

  The Relevance of Forensic Science  by Nnodim Johnkennedy in Journal of Clinical Case Reports Medical Images and Health Sciences. Abstract There is growing consensus that there is a crisis in forensic science at the global scale. Whilst restricted resources are clearly part of the root causes of the crisis, a contested identity of forensic science is also a significant factor. A consensus is needed on the identity of forensic science that encompasses what forensic science ‘is’, and critically, what it is ‘for’. A consistent and cogent identity that is developed collaboratively and accepted across the entire justice system is critical for establishing the different attributes of the crisis and being able to articulate effective solutions. The degree to which forensic science is considered to be a coherent, interdisciplinary yet unified discipline will determine how forensic science develops, the challenges it is able to address, and how successful it will be in ...